Based on my own research. Additions and corrections welcome (@ me), will update accordingly.
Total wide releases (600+ theaters):
155
Sequels, prequels, remakes, reboots, and franchises:
44
Based on novels (or comic books not previously made into films):
25
Based on a true story (BOATS):
30
Wholly original, not based on anything:
55
Documentaries:
1 (Born in China; An Inconvenient Sequel maxed out at 556 screens)
Wide releases with colons in their titles:
18
Wide releases directed by women:
15 (including one co-directed by a man)
Longest wide release title:
Pirates of the Caribbean: Dead Men Tell No Tales
Shortest wide release title:
Longest wide release:
Blade Runner 2049 (164 min)
Shortest wide release:
Beatriz at Dinner (82 min)
Female titles:
Wonder Woman, mother!, Girls Trip, A Bad Moms Christmas, Lady Bird, Lady Macbeth, The Zookeeper’s Wife, Megan Leavey, Maudie, Beatriz at Dinner, Ingrid Goes West, My Cousin Rachel, Jane, Citizen Jane, I, Tonya, Molly’s Game, The Women’s Balcony, Patti Cake$, Marjorie Prime, Thelma, We Love You, Sally Carmichael!, Coco, Annabelle: Creation, The Midwife, The Mummy
Male titles:
Father Figures, The Man Who Invented Christmas, The Book of Henry, The Resurrection of Gavin Stone, Brad’s Status, Goodbye Christopher Robin, Wilson, Tom of Finland, I, Daniel Blake, Dean, Logan, Daddy’s Home 2, John Wick: Chapter 2, Thor: Ragnarok, xXx: The Return of Xander Cage, King Arthur: Legend of the Sword, Ferdinand, The Bye Bye Man, The Greatest Showman, Spider-Man: Homecoming, Pirates of the Caribbean: Dead Men Tell No Tales, Roman J. Israel, Esq., Marshall, The Snowman, Loving Vincent, The Hitman’s Bodyguard, Chuck
Children’s titles:
Baby Driver, The Boss Baby, Diary of a Wimpy Kid: The Long Haul, Youth
Animal titles:
Rock Dog, A Dog’s Purpose, War for the Planet of the Apes, The Killing of a Sacred Deer, Wolf Warrior 2, Brigsby Bear, Beach Rats, Birth of the Dragon, Chasing the Dragon
Death titles:
Murder on the Orient Express, Happy Death Day, The Killing of a Sacred Deer, The Hitman’s Bodyguard, American Assassin
Shapely movies:
Kingsman: The Golden Circle, The Circle, Rings, The Square
Movies that were trying to confuse us:
– Logan, Lucky, Logan Lucky
– Wonder, Wonder Woman, Professor Marston and the Wonder Women, Wonderstruck, Wonder Wheel
– Fifty Shades Darker, Darkest Hour, The Dark Tower
– Rough Night, It Comes at Night, Sleepless
– A Ghost Story, Ghost in the Shell, City of Ghosts, Phantom Thread
Movies based on true stories that end with photos or film of the real people they’re about:
Maudie, Detroit, The Glass Castle, Crown Heights, Stronger, Battle of the Sexes, Marshall, Goodbye Christopher Robin, I, Tonya, The Disaster Artist, The Big Sick
Movies whose titles are never referenced or explained within the movies themselves:
Collide, Fifty Shades Darker, Going in Style, CHIPS, Unforgettable, Wonder Woman, The Killing of a Sacred Deer
Movies in which Wonder Woman is mentioned by name but does not appear:
Professor Marston and the Wonder Women
Movies in which Wonder Woman appears but is not mentioned by name:
Wonder Woman, Justice League, The LEGO Batman Movie
Movies in which cloistered women have affairs with groundskeepers:
Lady Macbeth, The Little Hours
Movies in which a nosebleed is precursor to more serious physical ills:
The Space Between Us, A Cure for Wellness, Rings, Raw
Movies in which someone hits a deer while driving to or from an eerie, exclusive community that has cult-like properties:
Movies about the evacuation at Dunkirk:
Dunkirk, Darkest Hour, Their Finest
Movies about sexual awakenings that end with Dad giving a speech that makes everything OK:
Movies in which enchanted beings are resurrected and physically transformed by the power of love:
Beauty and the Beast, Smurfs: The Lost Village
Movies in which someone at a shooting range aims for the crotch on the bad guy target:
War on Everyone, Going in Style
Movies in which a John Denver song is featured:
Free Fire, Alien: Covenant, Okja, Logan Lucky, Kingsman: The Golden Circle (plus a cover of “Take Me Home, Country Roads” in Diary of a Wimpy Kid: The Long Haul)
Movies in which a race of females encounters men for the first time, and one of the females was created from a lump of clay:
Smurfs: The Lost Village, Wonder Woman
Movies in which something that we’re told can be done by “no man” is done by a woman:
Wonder Woman, Pirates of the Caribbean: Dead Men Tell No Tales
Movies in which a cup of tea or coffee is suspected of being lethal:
Get Out, My Cousin Rachel, Suburbicon
Movies in which a white kid raps at a school talent show:
Movies in which a fist bump is greeted with a handshake:
Movies in which a pocket cassette recorder is important to the main character’s plans and the plot:
The Book of Henry, Baby Driver, Jigsaw
Movies that feature sign language:
Baby Driver, War for the Planet of the Apes, Novitiate, Wonderstruck, The Shape of Water, John Wick: Chapter 2
Movies in which a cat is eaten by a two-legged creature:
The Girls with All the Gifts, The Shape of Water
Movies in which John Goodman’s voice appears but not his body:
Transformers: The Last Knight, Valerian and the City of a Thousand Planets
Fact-based movies with seven-letter titles starting with D that are named after the war-torn locations they take place in:
Movies in which a group of prim, God-fearing adolescent girls are kept sequestered from the world but encounter evil anyway:
The Beguiled, Annabelle: Creation
Movies in which a group of ne’er-do-wells pull an elaborately planned heist and get away with it despite there being no moral justification for it:
Going in Style, Logan Lucky
Movies in which being high on drugs interferes with a woman’s musical performance:
Band Aid, Patti Cake$
Movies in which a mother exaggerates her child’s illness to keep the child close to her:
It, Everything, Everything
Movies that use scenes of captive animals to make you think of Nazi concentration camps:
War for the Planet of the Apes, Okja
Movies in which a couple breaks up but one of them soon has a life-threatening medical crisis that draws them back together:
The Big Sick, Stronger
Movies in which a major character is only ever known by a pronoun:
It in It; Him in mother!; It/Him in The Shape of Water
Movies in which six teenage ninjas in color-coded costumes are assembled to fight evil:
Power Rangers, The Lego Ninjago Movie
Movies with overt references to King Arthur, Excalibur, and/or the knights of the round table:
Transformers: The Last Knight, King Arthur: Legend of the Sword, Kingsman: The Golden Circle
Movies in which parents contemplate killing their own children:
Thelma, The Killing of a Sacred Deer, Suburbicon
Movies in which the primary antagonist is a clown with rabbit teeth:
It, Battle of the Sexes
Movies with characters who don’t know who their fathers are:
The Snowman, Wonderstruck, Father Figures
Movies in which someone is self-conscious about being from Sacramento while applying to colleges:
Brad’s Status, Lady Bird
Christmas-themed sequels to parenting-based comedies where the hook is that this time, the parents’ parents show up, and that end with the newly befriended grandparents going to Las Vegas together:
Daddy’s Home 2, A Bad Moms Christmas
Movies that begin with a brilliant legal mind finishing one case before being whisked away (by train) to the one the movie is focused on, and that end with him being hurried off (again by train) to the next one:
Marshall, Murder on the Orient Express
Movies that cover an entire school year, in which a teenage girl who is at odds with her mother auditions for a school play on a whim:
Lady Bird, Wonder
Movies with Wonder in the title in which a boy with a handicap is befriended by another boy in New York City:
Wonderstruck, Wonder
Movies in which a piece of fruit is used sexually:
Girls Trip, Call Me By Your Name
Movies featuring amphibious men with grotesque musculature:
The Shape of Water, Justice League
Movies in which the hulking main character is actually timid and mild, and in which one of his female companions is a proponent of dancing while fighting:
Jumanji: Welcome to the Jungle, Ferdinand
Movies in which people are hidden under a zoo by a zoo employee:
Split, The Zookeeper’s Wife
Fact-based movies that seek to rehabilitate the image of a female Olympic hopeful who has been popularly maligned since running afoul of the law:
I, Tonya, Molly’s Game
Movies with 10-letter titles and controversial racial politics in which Matt Damon plays an ineffectual suburban husband:
Suburbicon, Downsizing
Fact-based movies about an Englishman who gets impatient with a member of the household staff, fires her, and has to be chastened by his wife:
The Man Who Invented Christmas, Darkest Hour
Movies featuring Christopher Plummer as a miserly rich man who is forced by circumstances to examine his values:
The Man Who Invented Christmas (in which he learns his lesson), All the Money in the World (in which he does not).
Movies featuring Jaeden Lieberher as a boy with a crush on a girl who’s being sexually abused by her father:
The Book of Henry, It
Movies featuring Mark Hamill as a fundamentalist zealot who lives in an isolated bunker:
Brigsby Bear, Star Wars: The Last Jedi
Movies featuring Vin Diesel confronting a devious antagonist aboard her high-tech plane:
xXx: Return of Xander Cage, The Fate of the Furious
Movies set in the 1970s featuring Brie Larson and “Run Through the Jungle”:
Kong: Skull Island, Free Fire
Movies about a teenage girl repeatedly reliving the day of her death:
Before I Fall, Happy Death Day
Movies about office workers pitted against each other in a fight for their lives:
The Belko Experiment, Mayhem
(Thanks to @williambgoss for a few additions.)